2003

Schmid-Schönbein, G.W.: The second valve system in lymphatics. Lymphatic Research and Biology, 1:25-31, 2003.

Mendoza, E., Schmid-Schönbein, G.W.: A model for mechanics of primary lymphatic valves. J. Biomech. Eng., 125:407-413, 2003.

Sugihara-Seki, M., Schmid-Schönbein, G.W.: The fluid shear stress distribution on the membrane of leukocytes in the microcirculation. J. Biomech. Eng., 125:628-638, 2003.

Waldo, S. W., Rosario, H. S., Penn, A. H., Schmid-Schönbein, G.W.: Pancreatic digestive enzymes are potent generators of mediators for leukocyte activation and mortality. Shock, 20: 138 - 143, 2003.

Fitzal, F. , DeLano, F.A., Young, C., Rosário, H.S., Junger, W.G., Schmid-Schönbein, G.W.: Pancreatic enzymes sustain systemic inflammation after an initial endotoxin challenge. Surgery, 134:446-456, 2003.

Kramp, W. J. , Waldo, S., Schmid-Schönbein, G.W., Hoyt, D., Coimbra, R., and Hugli, T.E.: Characterization of two classes of pancreatic shock factors: Functional differences exhibited by hydrophilic and hydrophobic shock factors. Shock, 20:356-362, 2003

Fukuda,, S., Schmid-Schönbein, G.W.: Regulation of CD18 expression on neutrophils in response to fluid shear stress. Proc. Nat. Acad. Sci. U.S.A., 100:13152-13157, 2003.

2004

Delano, F.A., Schmid-Schönbein, G.W.: The glucocorticoid and mineralocorticoid receptor distribution in a microvascular network of the spontaneously hypertensive rat. Microcirculation, 11:69-78, 2004.

Doucet, J.J., Hoyt, D.B., Coimbra, R., Schmid-Schönbein, G.W., Junger, W.G., Wolf, P.L., Loomis, W.H., Hugli, T.E.: Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements following hemorrhagic shock. Journal of Trauma, 56:501-510, 2004.

Coughlin, M. F., Schmid-Schönbein, G.W.: Pseudopod projection and cell spreading of passive leukocytes in response to fluid shear stress. Biophysical J., 87: 2035-2042, 2004.

Ishimaru, K., Mitsuoka, H., Unno, N., Inuzuka, K., Nakamura, S., and Schmid-Schönbein, G.W.: Pancreatic proteases and inflammatory mediators in peritoneal ascites during splanchnic arterial occlusion and reperfusion. Shock, 22:467-471, 2004.

Fukuda, S., Mitsuoka, H., Schmid-Schönbein, G.W.: Leukocyte fluid shear stress response in the presence of glucocorticoid. J. Leuk. Biol,, 75:664-670, 2004.

Rosario, H.S., Waldo, S.W., Becker, S.A., Schmid-Schönbein, G.W.: Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the rat. Am. J. Pathol., 164:1707-1716, 2004.

Takase, S., Pascarella, L., Bergan, J.J., Schmid-Schönbein, G.W.: Hypertension-induced venous valve remodeling. J. Vasc. Surg., 39:1329-1334, 2004.

Fitzal, F., Delano, F.A., Young, C., Schmid-Schönbein, G.W.: Delayed intestinal protease inhibition after intestinal ischemia and reperfusion improves early symptoms of shock Arch. Surg, 139:1008-1016, 2004.

Fries, R.S., Mahboubi, P, Mahapatra, N.R., Mahata, S.K., Schlager, G., Schork, N.H., Schmid-Schönbein, G.W., O’Connor, D.T.: Neuroendocrine transcriptome in genetic hypertension: Multiple changes in diverse adrenal physiological systems. Hypertension, 43:1-11, 2004.

Artmann GM, Burns L, Canaves JM, Temiz-Artmann A, Schmid-Schönbein GW, Chien S, Maggakis-Kelemen C.: Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature. Eur. Biophys. J., 33:490-496, 2004.

Fukuda, F., Yasu, T., Kobayashi, N., Ikeda, N., Schmid-Schönbein, G.W.: Contribution of fluid shear response in leukocyte to hemodynamic resistance in the spontaneously hypertensive rat. Circ. Res., 95:100-108, 2004.

2005

Yasu, T., Greener, Y., Jablonski E., Killam, A.L., Fukuda, S., Suematsu, M., Tojo, S.J., Schmid-Schönbein, G.W.: Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules. Int. J. Cardiology, 98:245-252, 2005.

Schmid-Schönbein, GW: Capillary and venular responses to arterial hypertension. In: Microvascular Research: Biology And Pathology, D. Shepro (ed.), Elsevier Academic Press, Part III, Ch. 105, pp. 713-718, 2005.

Schmid-Schönbein, G.W.: Foundations of microlymphatic function. In: Microvascular Research: Biology And Pathology, D. Shepro (ed.), Elsevier Academic Press, Part I, Ch. 82, pp. 507-512, 2005.

Schmid-Schönbein, G.W., Hugli, T.: A new hypothesis for microvascular inflammation in shock and multi-organ failure: Self-digestion by pancreatic enzymes. Microcirculation, 12:71-82, 2005.

Kosawada, T., Inoue, K., Schmid-Schönbein, G.W.: Mechanics of curved plasma membrane vesicles: Resting shapes, membrane curvature, and in-plane shear elasticity. J. Biomech. Eng., 127:229-236, 2005.

DeLano, F. A., Balete, R. , Schmid-Schönbein, G. W.: Control of oxidative stress in the microcirculation of the spontaneously hypertensive rat. Am. J. Physiol. Heart Circ. Physiol., 288:H805-H812, 2005.

Makino, A., Glogauer, M., Bokoch, G.M., Chien, S., Schmid-Schönbein, G.W.: Control of neutrophil pseudopods by fluid shear: The role of Rho family GTPases. Am. J. Physiol. Cell: 288:C863 – C871, 2005.

Friese, R., Mahboubi, P., Mahapatra, N.R., Mahata, S.K., Printz, M.P., Schork, N.J., Schmid-Schönbein, G.W., and O’Connor, D.T.: Common genetic mechanisms of blood pressure elevation in two independent rodent models of human essential hypertension. Am J. Hypertension, 18:633-652, 2005.

Komai, Y., Schmid-Schönbein, G.W.: De-activation of neutrophils in suspension by fluid shear stress: A requirement for erythrocytes. Ann. Biomed. Eng., 33:1405-1416, 2005.

Blatnick, J., Sung, L. A., Schmid-Schönbein, G.W.: The influence of fluid shear stress on embryonic primary capillary plexus remodeling. Biomech. Model. Mechanobiol.,4:211-220, 2005.

Kobayashi, N., DeLano, F.A., Schmid-Schönbein, G.W.: Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneous hypertensive rats. Arteriosclerosis, Thrombosis and Vascular Biology, 25: 2114-2121, 2005.

Pascarella, L., Schmid-Schönbein, G.W., Bergan, J.J.: Microcirculation and venous ulcers: A review. Ann. Vasc. Surg., 19: 921-927, 2005.

2006

Schmid-Schönbein, G.W.: Analysis of inflammation. Ann. Rev. Bioeng., 8: 93-151, 2006.

Makino, A., Prossnitz, E.R., Bünemann, M., Wang, J.M., Yao, W., Schmid-Schönbein, G.W.: G Protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Am. J. Physiol, Cell, 290:C1633-C1639, 2006.

Lorenzen-Schmidt, I., Schmid-Schönbein, G.W., Giles, W.R., McCulloch, A.D., Chien, S., Omens, J.H.: Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem. Biophys., 46:113-122, 2006.

Kobayashi, N., Schmid-Schönbein, G.W.: Intrinsic disturbance of cellular redox balance enhances lymphocyte apoptosis in peripheral blood of spontaneously hypertensive rats. Free Radical Biology & Medicine, 41:484-492, 2006.

DeLano, F. A., Parks, D. A., Ruedi, J. M., Babior, B. M., Schmid-Schönbein, G. W.: Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive rat. Microcirculation, 13: 551-566, 2006.

Bergan, J. J., Schmid-Schönbein, G. W., Coleridge-Smith, P. D., Nicolaides, A., Boisseau, M. R., Eklof, B.: Pathogenesis of primary chronic venous disease: The role of inflammation. New Eng. J. Med., 355: 42-52, 2006.

Acosta, J. A., Hoyt D. B., Schmid-Schönbein G. W., Hugli, T.E., Angaria, D. J. , Frankel, D. A., Coimbra, R.: Intraluminal pancreatic serine protease activity, mucosal permeability and shock: A review. Shock, 26: 3-9, 2006.

Koroleva, O.I., Krystic, M., Schmid-Schönbein, G.W.: Decentralized and adaptive control of non-linear fluid flow networks. Int. J. Control, 79: 1495 – 1504, 2006.

2007

Penn, A. H., Hugli, T. E., Schmid-Schönbein, G.W.: Pancreatic enzymes generate cytotoxic mediators in the intestine. Shock, 27:296-304, 2007.

Wessel, J., Moratorio, G., Rao, F., Mahata, M., Zhang, L., Greene, W., Rana, B.K., Kennedy, B.P., Khandrika, S., Lillie, E.O., Smith, D. W., Wen, G., Hamilton, B.A., Ziegler, M.G., Witztum, J.L., Schork, N.J., Schmid-Schönbein, G.W., O’Connor, D.T.: C reactive protein, an “intermediate phenotype” for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J. Hypertension, 25:329-343, 2007. (see commentary).

Lynch, P.M., DeLano, F.A., Schmid-Schönbein, G.W.: The primary valves in the initial lymphatics during inflammation. Lymphatic Research and Biology, 5:3-10, 2007.

Tran, E., Schmid-Schönbein, G.W.: An in-vivo analysis of capillary stasis and endothelial apoptosis in a model of hypertension. Microcirculation, 14:793-804, 2007.

Murfee, W.L., Rappleye, J.W., Ceballos, M., Schmid-Schönbein, G.W.: Discontinuous expression of endothelial cell adhesion molecules along initial lymphatic vessels in mesentery: The primary valve structure. Lymphatic Research and Biology, 5:81-90, 2007

Schmid-Schönbein, G.W.: A journey with Tony Hugli up the Inflammatory Cascade towards the Auto-Digestion Hypothesis. International Immunopharmacology, 7:1845-1851, 2007.

Makino. A., Shin, H.Y., Komai, Y., Fukuda, S., Coughlin, M., Sugihara-Seki, M., and Schmid-Schönbein, G.W.: Mechanotransduction in leukocyte activation. Biorheology, 44:221-249, 2007.

2008

Penn, A.H., Kistler, E.B., Schmid-Schönbein, G.W.: Bioengineering of inflammation and cell activation: Autodigestion in shock. In: Bioengineering in Cell and Tissue Research. G. Artman, S. Chien eds., Chapter 21, Springer Verlag, Berlin, pp 511-527, 2008.

Pascarella, L., Lulic, D., Penn, A., Alsaigh, T., Lee, J., Shin, H., Kapur, V., Bergan, J.J., Schmid-Schönbein, G.W.: Mechanisms in experimental venous valve failure and their modification by Daflon© 500 mg. Europ. J.Vasc. Endovasc. Surg., 35:102-110, 2008.

Bergan, J.J., Pascarella, L., MD, Schmid-Schönbein, G.W.: Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertension. J. Vasc. Surg., 47:183-192, 2008.

Coughlin, M. F., Sohn, D. D., Schmid-Schönbein, G.W.: Recoil and stiffening by adherent leukocytes in response to fluid shear. Biophysical J, 94:1046-1051, 2008.

Shin, H.Y., Simon, S. I., and Schmid-Schönbein, G.W.: Fluid shear-induced activation and cleavage of CD18 during pseudopod retraction by human neutrophils. J. Cell Physiol., 214:528-536, 2008.

Su, S. S., and Schmid-Schönbein, G.W.: Fluid stresses on the membrane of migrating leukocytes. Ann Biomed. Eng., 36:298-307, 2008.

Hueck, I.S.., Rossiter, K., Artmann G.M., Schmid-Schönbein, G.W.: Fluid shear attenuates endothelial pseudopodia formation into the capillary lumen. Microcirculation, in press, 2008.

Penn, A.H., Schmid-Schönbein, G.W.: The intestine as source of cytotoxic mediators in shock: Free fatty acids and degradation of lipid-binding proteins. Am. J. Physiol. Heart Circ., 294:H1779-H1792, 2008.

DeLano, F.A., Schmid-Schönbein, G.W.: Proteinase activity and receptor cleavage: Mechanism for insulin resistance in spontaneously hypertensive rat. Hypertension, 52: 415-423, 2008. See commentary: Metalloproteinases Damage the Insulin Receptor to Cause Insulin Resistance in Spontaneously Hypertensive Rats. Bohlen, H.G., Hypertension, Online, June 9, 2008. Vol. 52:1-3.

Schmid-Schönbein, G.W.: Biomechanical aspects of the auto-digestion theory. Molecular & Cellular Biomechanics, 5:83-95, 2008.

Friese, R.S., Rao F., Khandrika S., Thomas B., Ziegler M. G., Schmid-Schönbein G. W., O'Connor D.T.: Matrix metalloproteinases: Discrete elevations in essential hypertension and hypertensive end-stage renal disease. Clinical and Experimental Hypertension, in press, 2008.