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The Autodigestion Hypothesis
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Since the discovery of superoxyde dismutase (J. M. McCord and I. Fridovich, 1969) the Oxygen Free Radical Hypothesis has received close attention as potential mechanisms for cell and tissue injury in aging and in many pathologies. In 2005 we postulated that there exists a second tissue injury mechanism that we coined the Auto-Digestion Hypothesis.  |
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| Relevant Publications: | |
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Schmid-Schönbein, G.W., Hugli, T.: A new hypothesis for microvascular inflammation in shock and multi-organ failure: Self-digestion by pancreatic enzymes. Microcirculation, 12:71-82, 2005. Schmid-Schönbein, G.W.: A journey with Tony Hugli up the Inflammatory Cascade towards the Auto-Digestion Hypothesis. International Immunopharmacology, 7:1845-1851, 2007 Schmid-Schönbein, G.W.: Biomechanical aspects of the auto-digestion theory. Molecular & Cellular Biomechanics, 5:83-95, 2008. |
