Klaus M. Hahn

Associate Professor, Department of Cell Biology, Scripps Research Institute
Degrees and Awards:
Ph.D., University of Virginia, 1986

National Institutes of Health James A. Shannon Director's Award, 1998

Research Interests:
New approaches to quantify/control the spatio-temporal dynamics of signaling in living cells.
Signaling in cell motility - Rho family proteins and adhesion in "long range" coordination/communication across the cell.
Spatio-temporal control of signaling networks - multiple functions of MAP kinase pathways.

Selected Publications:

  • Kraynov, V. S., Chamberlain, C. E., Bokoch, G. M., Schwartz, M. A., Slabaugh, S., and K. M. Hahn. Localized Rac Activation Dynamics Visualized in Living Cells. Science, 290:333-337, 2000.
  • Hahn, K. and Toutchkine, A. Live cell fluorescent biosensors for activated signaling proteins. Curr. Op Cell Biol. 14:167-172, 2002.
  • Del Pozo, M.A., Kiosses, W.B., Alderson, N.D., Meller, N., Hahn, K.M. and Schwartz, M. A. Integrin regulated membrane translocation of GTP-Rac induces localized interaction with effectors due to dissociation of RhoGDI, Nature Cell Biol., 4:232-239, 2002.
  • Toutchkine, A., Nalbant, P. and Hahn, K.M. Facile synthesis of thiol-reactive Cy3 andCy5 derivatives with enhanced water solubility. Bioconjugate Chem., 3:386-389, 2002.
  • Toutchkine, A., Kraynov, V.S., and Hahn, K.M. Solvatochromic Dyes to Report Protein Conformational Changes in Living Cells.
Research Figure: