Newsletter of the Whitaker Institute of Biomedical Engineering
University of California, San Diego May 2001 Vol. 8, No. 1 


Message from the Director

It is my pleasure to report that the WIBE received a favorable 5-year review, and the review committee recommended its continuation. (page 3). I wish to thank all members and friends of WIBE for your wonderful work and support, which are essential for the Institute’s success.

The UC system-wide Bioengineering Steering Committee submitted a proposal for the establishment of a Multicampus Organized Research Unit entitled Bioengineering Institute in California was submitted for review. (page 4). The Second UC System-wide Bioengineering Symposium held in UC Santa Barbara on May 6-7 was a great success (page 4).

On February 15, 2001, the Whitaker Institute for Biomedical EngineeringWIBE Project sponsored the first Conference on Glucose Monitoring and Control sponsored its first Conference.Dr. David Gough, Chair of the Department of Bioengineering, and member of the Whitaker Institute for Biomedical Engineering served as Director of the Project, was responsible for the organization of this successful The project involved many UCSD participants and industrial affiliates. The conference.Over 90Approximately one hundred attendees participated, and the plan is to make this an annual event.

The 15h Annual Bioengineering Graduate Research Symposium took place on March 10, 2001.The graduate students presented their research to fellow students, faculty, and scientists in academia and industry.The symposium was made possible by the generous support of the UCSD Graduate Student Association, UCSD Office of Graduate Studies and Research,and the UCSD Department of Bioengineering, and WIBE Industrial Advisory Board.

On January 26, 2001, the WIBE in conjunction with UCSD CONNECT held a Meet the Researchers Series, which featured GlySens, Inc., a company developing a new system for monitoring glucose levels (page 2).

The Zweifach Memorial Lecture was given by Dr. Charles Michel on March 14, and the Skalak Memorial Lecture was delivered by Dr. Douglas Lauffenburger on April 30. (page9).

We are currently in the building phase of theThe new Powell-Focht Bioengineering Building is actively under construction.The fivefive-story 105,000 sq. ft. facility was made possible by the Whitaker Foundation’s Leadership Award of $18.2 million, the Charles Lee Powell Foundation’s gift of $8 million, and other generous contributions. In this new Building, there will be the Y.C. Fung Auditorium to honor Dr. Y.C. Fung, who recently received the President’s National Medial of Science, the nation’s highest scientific honor (page 10) and the Benjamin W. Zweifach Library to honor the late Dr. Zweifach.

We are pleased to feature Dr. Giovanni Paternostro, of the Burnham Institute, the newest member of the WIBE (page 5).

Congratulations to WIBE members and students for their awards and honors. Dr. Sindhu Goplan for being this year’s top ranked AHA, Western States Affiliate postdoctoral fellowship applicant (page 10-12).

August 8-11, 2001, the 25th Annual Meeting of the American Society of Biomechanics (ASB) will be held in San Diego, California at the UCSD campus. (page 5).

-Shu Chien, Director, WIBE


Dr. Joseph Lucisano

President & CEO GlySens, Inc.

Dr. Lucisano serves as President & CEO of GlySens, Inc. a start-up company located at 6540 Lusk Boulevard, Suite E-109 in San Diego.The facility consists of three offices and two laboratories.GlySens, Inc. is developing a glucose monitoring system, which enables people with diabetes to gain better control over the disease.

GlySens, Inc. was based in part on Dr. David Gough’s research on implantable glucose sensors.Dr. Gough is Chair and Professor of Bioengineering at UCSD and serves as Chief Scientist at GlySens, Inc.

The two met when Lucisano was a graduate student in Dr. Gough’s lab group.Dr. Lucisano was part of the team that developed a glucose sensor and radio-telemetry system which functioned over 100 days without recalibration in an animal test.

Dr. Lucisano and Dr. Gough together at Meet the Researcher Series sponsored by UCSD CONNECT and the Whitaker Institute of Biomedical Engineering (WIBE) on January 26, 2001 presented their technologies, products and ideas behind GlySens, Inc.

Diabetes is known as the silent killer. It is a disease in which the body does not produce or properly use insulin, a hormone needed to convert food, sugar and starches into energy.There are 15.7 million people in the United States suffering from the chronic disease.Diabetes can cause blindness, kidney disease, nerve disease, heart disease, stroke and loss of limbs.The glucose monitoring system will enable the patient suffering from the disease to detect their glucose levels without “pricking” themselves and better monitor and regulate their levels.

In August 2000, the San Diego Regional Technology Alliance (RTA) announced a $1.4 million award in seed capital to San Diego firms as part of the California Technology Investment Partnership (CalTIP) program.GlySens, Inc. was awarded $175,000 to develop the glucose sensor.

This particular sensor will be implanted in the patient’s body tissue.This is considered much less invasive then implanting the device directly in the bloodstream.Glucose levels can be measured in the tissue fluid and transmitted via an implanted enzyme-electrode sensor to an external display.

For more information about GlySens, Inc. please contact Dr. Joseph Lucisano at joelucisano@glysens.com.


Five-Year Review of the Whitaker Institute of Biomedical Engineering

All Organized Research Units (WIBE is one of them) in the University of California are subject to five-year reviews, which assess the past accomplishments, present status and future developments.

TheWIBE five-year review committee appointed by Vice Chancellor Richard Attiyeh of the Office of Graduate Studies and Research conducted an in-depth review in year 2000.

In general, the review was very positive, as indicated by comments such as: “The founding of the WIBE contributed significantly to the visibility of bioengineering at UCSD”.The students and faculty in other departments and ORUs at UCSD have benefited in several ways, including the fostering of research collaboration, access to the Core Facilities, the seminar series, and partnerships with industry.The Institute has been the primary contact between UCSD and other institutions and industries, which has enriched the education of students who have had the opportunity for internships outside UCSD.The Institute was pivotal in the creation of the department, was instrumental in improving its ranking and assisted in attracting research funding.” “For multidisciplinary research within the SOM and UCSD, the research themes being carried forward within the WIBE are defined in a flexible manner providing the WIBE with a structure that appeared to this committee as being inclusive.” “The WIBE serves as an inspiration for other ORUs and as a source of pride for faculty in other departments.It has established an enviable record of success that others hope to emulate.” “The WIBE has an active industrial affiliates program that both benefits the public and brings valuable publicity to UCSD. The Institute has been recognized by the Whitaker Foundation as one of the leading centers for biomedical engineering in the nation.

The committee is supportive of WIBE’s effort with other UC campuses to form a Multicampus Organized Research Unit, which would serve to coordinate all Bioengineering Programs in the UC system.

The committee concluded that the WIBE should not be discontinued and that the campus will be best served over the next five years if Shu Chien is allowed to serve one more term as the Director.

The committee has made several thoughtful and constructive recommendation for the WIBE;

·To appoint an associate director.

·To strengthen its participation in the Division of Biology, especially in relation to the new revolution in bioinformatics and computational biology. 

·To become more active in recruiting senior researchers and faculty to the campus. 

·To facilitate the advising of Bioengineering graduate students by WIBE faculty outside the Bioengineering Department. 

·To extend WIBE’s Industrial Affiliates Program to raise support from relevant industry throughout US and to enhance industry supported research programs. 

·To develop outreach programs to the local community and schools.

These are very valuable recommendations, and every effort will be made to work in these directions.


University of California System-wide Activities 

in Bioengineering


Planning of a Multi-campus Organized Research Unit on Bioengineering

At the invitation of WIBE, Bioengineering representatives from eight University of California campuses (Berkeley, Davis, Irvine, Los Angeles, Riverside, San Francisco, Santa Barbara, and San Diego) met to discuss initiatives to foster biomedical engineering in the University of California system-wide.A steering committee was formed by representatives of all these campus. The committee has met six times during the last year and half, with the most recent meetings this year on March 16 at UCLA and May 7 at UC Santa Barbara.

The Steering Committee has submitted a proposal to establish a multi-campus MRU (Bioengineering Institute in California), with UCSD as the initial headquarters.This proposal is being reviewed by the UCSD Office of Graduate Studies and Research and Academic Senate, prior to its submission to the Office of the President and to the other campuses for further reviews.

The establishment of this MRU will allow bioengineering programs in the UC system to leverage the collective strengths on bioengineering and related areas for the enhancement of research and education.The goal of the MRU is to work synergistically to meet the grand challenge of integrating and synthesizing the information generated in biomedical and engineering sciences to advance the field of bioengineering for the improvement of health and well being of our citizens and society.

UC System-wide 

Bioengineering Symposium

One of the initiatives of the UC Steering Committee on Bioengineering is to hold annual symposia that foster the exchange and collaboration among the campuses.The First Annual UC System-wide Bioengineering Symposium was held at UC Davis on April 30-May 1, 2000, with approximately one hundred participants from the eight campuses.

On May 6-7, 2001 the Second Annual Symposium was held in UC Santa Barbara, and the participants rose to two hundreds, with a good representation from UCSD.The Symposium consists of oral and poster presentations organized in five sessions (Biomaterials, Nanosystems, Biotechnology, Biofluids and Computation). The presentations were uniformly of high quality, and most of the presenters were students and young scientists.

These two Symposia were extremely successful in fostering the interaction and collaboration among research groups in differentcampuses working on related topics.



 

Announcements

 

American Society of Biomechanics: The 25th Annual Meeting of the American Society of Biomechanics at the University of California, San Diego, will be held on August 8-11, 2001. The conference will bring together 300-500 engineers and biologists who will present their research. The American Society of Biomechanics is pleased to annually award the Giovanni Borelli Award, the Pre- and Post-Doctoral Young Scientist Awards, the Journal of Biomechanics Award, the Clinical Biomechanics Award, the ASB-Microstrain Award the ASB Travel Fellowship and Student Travel Awards. Nominations are currently being accepted. The meeting is cosponsored by the UCSD Department of Bioengineering as well as the Whitaker Institute of Biomedical Engineering. For more information please see http://www-bioeng.ucsd.edu/homepage.html or contact Dr. Richard Lieber at rlieber@ucsd.edu.

 

2001 Annual Bioengineering Industrial Internship Meeting: The 4th Annual Gathering took place on May 16, 2001 at the Price Center. Industry, faculty and a large number of students participated in this annual gathering. The meeting led to fruitful exchanges among the participants, especially the linkage between industry and students. Industry mentors are welcomed for take active roles in both the Industrial Internship and Graduate Training Programs for this upcoming Summer and future quarters. For further questions, please contact Imani Tyus at (858) 822-4769 or ityus@bioeng.ucsd.edu

 

Dr. Gang Jin, who graduated from the Ph.D. program in Department of Bioengineering, UCSD, recently moved onassumed the position in a industry company as theof Director and Principal Scientist of Genomics Lab in Purdue Pharma Ltd.  at Irvine, CA, which is a leader pharmaceutical company in the world for pain drug development. He resigned his position ofPrior to joining Purdue Pharma, Dr. Jin was Director and Staff Scientist of Functional Genomics Center in the Salk Institute since April 8, 2001, where he established the microarray technologies for the Salk Microarray Core. 

Dr. Peter Butler, Postgraduate Researcher in Bioengineering, will take a faculty position as Assistant Professor of Biomedical Engineering at the Pennsylvania State University in August 2001.

 

U.S. News & World Report magazine survey ranked the Jacobs School of Engineering 10th among public universities and second, behind UC Berkeley, in the University of California system. In the overall national rankings, the JOSE came in 16th. Bioengineering ranked 3rdnin the nation. The UCSD School of Medicine ranked 24th and continues to be ranked among the top 25 medical schools in the nation. The SOM drug and alcohol-abuse program was ranked 10th. 

 

John F. Hansbrough, M.D.: We note with sorrow the passing of John F. Hansbrough, M.D., Professor of Surgery, and Director of the UCSD Regional Burn Center, and a WIBE member, died unexpectedly on March 7, 2001. 

 



WIBE Member 

Marcos Intaglietta


Prof. Marcos Intaglietta joined the UCSD faculty in 1966 and formed the original Bioengineering group together with Profs. Y.C Fung and B.W. Zweifach.He is a U.C. Berkeley Mechanical Engineering graduate, and has Ph.D. in Applied Mechanics from Caltech. Prof. Intaglietta began his career developing quantitative methods for the study of the microcirculation.The instruments that he produced have been deployed world wide, and provided the opportunity for obtaining a basic understanding of the physiology of fluid exchange, kidney function, cancer research and the development artificial blood.These instruments blend mechanics, optics, and electronics in order to obtain data from the realm of in vivo microscopic blood vessels.This enterprise developed through the 70's and 80's continues through the development of a methodology for measuring oxygen tension in microscopic domains by optical means.

Dr. Giovanni Paternostro, Research Investigator at The Burnham Institute joined the WIBE on April 19, 2001.Dr. Paternostro received his M.D. from the University of Rome, Italy, in 1987, M.Sc., from the University of London, U.K., in 1990, and his Ph.D. from the University of Oxford, U.K., in 1997.

Anticipating current trends, he insured early on that his instruments be rapidly commercialized, thus undergoing the rigorous testing and validation of the marketplace causing his laboratory to be recognized as a national and international facility for the application of engineering methods to biological and medical problems.As a consequence Prof. Intaglietta trained and collaborated with many of the European, Latin American and Asian leaders in the field of microcirculation. 

Prof. Intaglietta=s most salient and fruitful collaborations in the U.S. have been with Prof. Rakesh K. Jain at Harvard Medical School, and the Department of Physiology formerly directed by Prof. Paul C. Johnson at Tucson, Arizona.He is well known in Latin America, where he has lectured extensively, aided by his fluency in Spanish.He has a long standing collaboration with Prof. Eishun Tsuchidahead of Polymer Chemistry at Waseda University, Tokyo, and head of the Japanese program for the development of artificial blood with whom he is developing the next generation artificial blood products based on micro-encapsulation technologyand microcirculation experiment-ation.

The developed of quantitative technology with which to study in vivo cellular events allowed Prof. Intaglietta to investigate early on the fluid and gas exchange processes that occur at the level of microscopic blood vessel, and how to apply these findings to the study of blood replacement, hemorrhage and artificial blood.By means of his instrumentation, measurement techniques and animal models, analysis of the biomechanics of fluid and gas management process at the microscopic level, and experiments that challenged existing preconceptions of the roles of blood viscosity, oxygen delivery and in fluid. balance in the microcirculation, he has produced the conceptual breakthroughs that make artificial blood possible, effective and economic.This achievement came about through the collaboration with Prof. Robert M. Winslow, formerly from the UCSD Department of Medicine with whom he was recently awarded two US patents, leading to the establishment of a Sangart Inc., San Diego, a science based company dedicated to the development and manufacture of blood substitutes.Prof. Intaglietta chairs the Scientific Advisory Board of Sangart Inc.

Prof. Intaglietta is known to both our undergraduate and graduate students through this teaching activities.He has bee for the past 15 years in charge of the Senior Engineering Design course, which is required for graduating ABET Bioengineering Seniors. This course has uninterruptedly presented to our graduating students current Bioengineering design problems and projects, dealing with applications of new technologies, their potential for innovation and the related economic considerations.Since joining UCSD he has thought the Graduate Transport Phenomena course, which presents exchange process in living system from the viewpoint of irreversible thermodynamics.At the departmental level Prof. Intaglietta has provided continuity to our graduate admission policies by serving on the Graduate Admissions Committee for thepast two decades.

In terms of funded research he is the Principal Investigator of an NIH Bioengineering Research Partnership for the development of artificial blood and was recently awarded two NIH R01 grants, dealing with the theory of tissue oxygenation and the development of high viscosity plasma expanders.His laboratory, shared with Prof. Paul C. Johnson and directed by Dr. Amy G. Tsai, combines in vivo microscopy and electro-optical instrumentation development.His hypothesis that a minimum level of blood viscosity is necessary for maintaining optimal research deals with the theory of how oxygen is used in the body, and is driven by his findings indicating that most of the oxygen is used by the blood vessels.He has recently developed the mechanical conditions in the circulation.These concepts form the basis of the work of his Bioengineering Partnership program and converge in the development of oxygen carrying blood volume replacement fluids.

Prof. Intaglietta has been recognized by his research and academic achievements receiving the Whitaker Award for the Bioengineering Society and the Landis and the Malpighi Awards from the American and European Societies for Microcirculation.Those who do not know him personally may easily recognized him because he is one of the persons who consistently wears a tie.


WIBE Visiting Scientists

G.B. Bourne, University of Calgary, is currently working with Dr. Robert E. Shadwick of The Scripps Institution of Oceanography.

Henrique De Rosario is working on cell activation in physiological shock with Dr. Geert Schmid-Schönbein.

Florian Fitzal is working on a new treatment modality for physiological shock with Dr. Geert Schmid-Schönbein.

WIBE Visiting Scientists

Alexander Giurea, an orthopaedic surgeon from Vienna Austria is working in a collaborative project between Dr. Robert Sah of Bioengineering, Dr. David Amiel and Dr. Wayne Akeson of Orthopaedic Surgery.

Anushka Michailova, Professor of Biophysics, Bulgarian Institute of Biophysics, Sofia, is working with Dr. Andrew McCulloch.

Kyo Mun is working on a problem of inflammation in arterial hypertension with Dr. Geert Schmid-Schönbein.

Franci Weyts from the University of Erasmus of Rottadam, The Netherlands, is working on the role of integrins in signal transduction of bond cells in health and disease with Dr. Shu Chien.


Professor Charles Michel Gave Zweifach Memorial Lecture

The Benjamin W. Zweifach Memorial Lecture was established to honor the late Professor Zweifach, who co-founded the UCSD Bioengineering Program with Professor Y.C. Fung.Dr. Zweifach has made seminal contributions to research on the microcirculation, and is often referred to as the father of microcirculation research.This year’s lecturer is Professor Charles Michel. On March 14, 2001 he gave the lecture entitled "Flow Dependent Permeability and the Physiological Regulation of Microvascular Exchange". Professor Michel presented direct evidence that the permeability to fluid transport across blood vessels in the microcirculation is determined by the fluid shear stress applied to the endothelial cells.

Professor Michel is Emeritus and Senior Research Investigator in the Section of Cellular and Integrative Biology of the Division of Biomedical Sciences at the Imperial College for Technology School of Medicine London, Great Britain. Previously he was Professor of Physiology & Head of the Department of Physiology & Biophysics, St Mary’s Hospital Medical School, London.Among many distinguished achievements, Professor Michel in Honorary Member of the British and the American Physiological Society, Fellow of Royal Society of Medicine and former President of the British Microcirculatory Society.

Professor Michel has established a distinguished research record in the study of molecular transport across the endothelium in living tissues.He proposed with Dr. F. Curry at UC Davis the fiber matrix theory of capillary permeability.He pioneered the study of transvascular fluid transport in counter-current exchange systems, the role of leukocyte rheology in venous diseases in the leg, and recently demonstrated transcellular openings in the cytoplasm of endothelial cells under fluid pressure.

Dr. David Gough, Chairof Bioengineering;

Dr. Charles Michel, the Zweifach Lecturer, and Dr. Geert W. Schmid-Schönbein, Professor of Bioengineering, following the Zweifach Memorial Lecture on March 14, 2001


 

Professor Douglas Lauffenburger was Skalak Memorial Lecturer

The Richard Skalak Memorial Lecture was established to honor the late Professor Skalak, who was Professor of Bioengineering and Director of the Institute of Mechanics and Materials at UCSD.Professor Skalak made outstanding contributions to the field of cell biomechanics.This year’s lecturer is Dr. Douglas Lauffenburger, [Need to fill titles]Dr. Lauffenburger has received many awards and honors for his outstanding contributions to bioengineering.He was President of the Biomedical Engineering Society.He is Chair of College of Fellows of the American Institute for Medical and Biological Engineering and a member of the National Academy of Engineering.

Dr. Lauffenburger’s lecture on “Operation of EGF Receptor Autocrine Signaling Loops: A Combined Experimental and Computational Study“ provided new insights into the mechanisms by which the epidermal growth factor receptor serves as a key element in the regulation of the autocrine signaling loops in mediating cellular functions.


IBME WIBE Faculty Honors

Dirk-Uwe BartschAssistant Professor in Residence at the Shiley Eye Center received and NIH grant for the use of adaptive optics in ophthalmology.His proposal is entitled “High-Resolution Imaging of Ocular Melanoma and Retina”.The granting agency is the National Institutes of Health / National Eye Institute.Dr. Bartsch was awarded $1,096,028.

Colin M. Bloor, Professor of Pathology, was recently appointed to be Deputy Editor of the international Society of Heart Research’s publication – Heart News and Views – the official News bulletin of ISHR published by support of an educational grant from Servier International.He will become editor in 2004 when the current editor’s term ends.At the XVII World Congress of the International Society for Heart Research on July 6-11, 2001, he will present at the symposium on exercise (???).In addition, aAt the World Congress (Is this correct??), another symposium has been named the “Colin Bloor Symposium: Vascular Biology and Angiogenesis” in his honor.Dr on Basic Cardiovascular Sciences of the American Heart Association.

Yuan-Cheng Fung, Professor Emeritus of Bioengineering, recently received the President’s National Medal of Science, the nation’s highest scientific honor.President Clinton paid tribute to the man fondly known as the father of biomechanics at an awards dinner in December 2000.Dr. Fung was also recognized by Chancellor Robert Dynes and Senior Vice Chancellor Marsha Chandler, along with 200 guests, at the University House on March 26th.In the 38-year history of the President’s National Medal of Science, Dr. Fung is the first bioengineer to receive the award.Dr. Fung adds this award to his long list of honors that include the Founder’s Award from the National Academy of Engineering (1998), the Bioengineering Award from the Japan Society of Mechanical Engineering (1995), the Distinguished Alumnus Award from California Institute of Technology (1994), the Timoshenko Medal (1991), and the Melville Medal (1994) from the American Society of Mechanical Engineers, the Borelli Award from the American Society of Biomechanics (1992), and the Lifetime Achievement Award from the Association of Chinese Scientists and Engineers of California (1992).In 1986 the ASME established the “Y.C. Fung Young Investigator Award” in his honor.Dr. Fung is one of the few individuals to be elected a member of all three brances of the National Academiesy.

Gordon Gill – Please see UCSD website for his new appointment in the School of Medicine.has been named Interim Dean for Scientific Affairs for the UCSD School of Medicine.Dr. Gill, Professor of Medicine, has been a UCSD physican-scientist for the last 32 years.He also serves as chair of the Faculty of Basic Biomedical Sciences.He has served on numerous scientific boards.His honors include the Research Career Development Award from the NIH and he is a fellow of the American Academy of Arts and Sciences.Dr. Gill has been a key participant in the growth of medical research at UCSD. 

Alan F. Hofmann, Professor (Emeritus) of Medicine, on May 17thwill receive on May 17th, 2001 the Distinguished Alumnus Award from the Mayo Clinic and Mayo Foundation (Rochester, Minnesota), where he worked between 1966 and 1977.

Gary A. Huber, Assistant Professor Bioengineering, recently received a NSF CAREER award. This 5-year award will fund his work in developing multi-scale computer simulation algorithms and software for studying large biological molecules.

[More info ……]

Robert L. Sah, Associate Professor Bioengineering, and an affiliate of the department of Orthopaedics, was awarded Kappa Delta’s Young Investigator Award.His paper is entitled “Articular Cartilage Tissue Engineering: Biological and Biomechanical Foundations.”The award was given for a series of studies that Dr. Sah conducted during the past eight years in the field of cartilage tissue engineering.[If the award is recognition of a series of studies, why was one paper mentioned at the beginning.I am confused.]Dr. Sah’s research was is directed at determining the cellular, biochemical and physical conditions that will foster cartilage regeneration, repair and long-term stability.

John B. West, Professor of Medicine and Physiology, has been elected to the American Academy of Arts and Sciences.Dr. West has made important contributions in physiology and medicine during the last 40 years.He studied human respiration at ever-increasing altitudes from sea level to the high Andes, Mount Everest, and, recently, outer space.This year's election continues the Academy's tradition of honoring intellectual achievement, leadership, and creativity.

Researchers’ Student Honors

Sindhu Gopalan, PG Postgraduate Researcherin Bioengineering, is this year’s top ranked American Heart Association (AHA), Western States Affiliate postdoctoral fellowship applicant.Dr. Sindhu Gopalan works in the Cardiac Mechanics Research group was this year's top ranked American Heart Association (AHA), Western States Affiliate postdoctoral fellowship applicant. Her award-winning proposal was entitled "Role of the Cytoskeleton in Myocyte Hypertrophic Responses to Physical Stress", and her sponsor is Professor Andrew McCulloch in the Cardiac Mechanics Research group of the Department of BioengineeringBut sShe is also working jointly with Professors Sangeeta Bhatia, Jeff Omens and Ken Chien.

Mechanical stress and strain are widely thought to be primary signals regulating cardiac hypertrophy and remodeling, including transition from compensated hypertrophy to heart failure. Cell to cell and cell to matrix interactions are thought to be an important feature in the responses of myocytes to external load. Myocyte­matrix interactions also regulate cell shapes and are also likely to influence echanotransduction via integrin-dependent and matrix specific pathways that could well involve the cytoskeleton. Thus if cytoskeletal components are disrupted, biological forms of hypertrophy may be present with non-compensatory forms of hypertrophy during the onset of heart failure. Dr. Gopalan proposes to use

microfabrication technologies in collaboration with Dr. Bhatia's laboratory to micropattern neonatal cardiac myocytes to better replicate in-vivo cell morphology and remodeling responses. A novel elliptical cell stretcher is being used to investigate the effects of anisotropic mechanical loading. By

using cells from mice harboring cytoskeletal gene mutations in collaboration with Drs. Omens and Chien, Dr. Gopalan will investigate the hypothesis that specific components of the myocyte cytoskeleton are involved in the signalling pathways that regulate normal cell shape- and load-dependent

hypertrophic responses.

Dr. Gopalan joined the Bioengineering Department in April 2000. She earned her PhD degree from the Sree Chitra Tirunal Institute for Biomedical Science and Technology, Kerala, INDIA. In her PhD research she worked on biomaterials processing approaches for preventing calcification, the major

complication of bioprosthetic tissue heart valves as well as thrombosis of bioimplants in general. She developed a tissue polymer hybrid material from double crosslinked bovine pericardium and polyethylene glycol. It was successfully evaluated for biocompatibility, tissue stability, microscopic

and histological observation and further implantation in rat subcutaneous models for long periods. She also investigated site-specific controlled delivery of anticalcifying and antithrombotic drug combination in low levels. Both approaches separately and in combination had a synergistic effect in inhibiting tissue calcification.

Dr, Gopalan's new AHA fellowship will begin on July 1st and has a tenure of 2 years.Her long-range professional aim is to work in academic research in cardiovascular disease especially in the fields of micro-tissue engineering, biomaterials and cell-matrix interactions.

As a top ranked award recipients Dr Gopalan will receive special recognition from the AHA in the form of a named honorary award and plaque.  She will also attend the Annual Delegate Assembly to receive her award.

Student Honors

Salman Khetani has been awarded an NSF Fellowship

Melissa Kurtis, a fifth year Ph.D. student in Dr. Sah's Cartilage Tissue Engineering

Lab,  received a Selected Professions Engineering  Dissertation Fellowship from the American Association of University Women  (AAUW) in December 2000. These fellowships are awarded to cover academic and living expenses during the final year of a dissertation. The amount of the award was $15,000.

Mihri Ozkanwon 2001 Jacobs School of Engineering Graduate Student Grand Prize for my electrically assisted cellular microarraying study.She is currently working with Dr. Sadik Esener (ECE) and DrSangeeta Bhatia. 

Jason Papin has been awarded a Whitaker Fellowship.

Tom Pisanic has been awarded a National Defense Science and Engineering Graduate Fellowship.

New Bioengineering Ph.D.’s and Their Current Positions

Jeff Bishop, Ph.D. - Research Scientist, Biosite Diagnostics, San Diego, CA

Miguel Bravo-Zanoguera, Ph.D. -Professor,UniversidadAutonomadeBajaCalifornia,Mexicali,Mexico

Twana Davisson Howard, Ph.D.- Research Scientist, Advance Tissue Sciences, Inc., La Jolla, CA

Derrick Sung, Ph.D.- Consultant, The Boston Consulting Group, Los Angeles, CA

Richard Suzuki, Ph.D.- Postdoctoral Fellow, Dept of Bioengineering, UCSD

Sara Weiss, Ph.D.- Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA

Congratulations to all!

There must be other student honors, e.g., Whitaker Foundation Award, NSF Award, AHA Award, etc.Please check with Irene and Jorrie.

University of California, San Diego

Whitaker Institute of Biomedical Engineering

9500 Gilman Drive

La Jolla, CA 92093-0427

(858) 822-2290