Newsletter 
of the Whitaker Institute of Biomedical Engineering

University of California, San Diego                                                                                              October 2001      Vol. 8, No. 2

Industrial Profile GENOPTIX

Am. Society of Biomechanics Meeting

William J. von Liebig Center

WIBE Announcements

WIBE Profile: Michael J. Heller

WIBE Visiting Scientists/New PhD’s

Bioengineering Seminar Schedule

Dr. Sah’s Young Investigator Award

Researchers’ Honors

Student Honors

New Bioengineering Graduate Students

Industrial Profile: Genoptix

Genoptix is developing a revolutionary technology aimed at fundamentally changing the nature of cellular analysis.  The cell represents the true point of integration for all biological processes and genomic information.  In the post-genomics era, accessing and deciphering this information will be key to the successful development of new drugs and the diagnosis and treatment of disease.  No existing technology efficiently and comprehensively addresses the enormous complexity of this information.

Genoptix proprietary Optophoresis™ technology is the only technology capable of simultaneously analyzing, selecting and moving specific cells based on their intrinsic optical dielectric properties. The technology utilizes lasers in the near infrared wavelength range to create moving optical gradients which are used to selectively characterize and separate cells based on these innate properties.  This approach represents the first practical method for probing the inner workings of intact living cells without the need for any dyes, labels or other markers, which fundamentally differentiates Genoptix technology from all other current methodologies.

This technology allows for the determination of individual “Optophoretic Constants” which provide cells with unique signatures and facilitate their rapid characterization and separation another.  These Optophoretic Constants uniquely reflect the physiological state of individual cells at the exact moment at which they are being analyzed, allowing the researcher to simply and efficiently gather a wide spectrum of information, from screening new drugs, to studying the expression levels of novel genes, to creating new diagnostic products, even to monitoring cancer patients.  Genoptix technology provides a revolutionary way to link the intricate mechanisms involving the living cell’s overall activity with uniquely identifiable optophoretic parameters.

For more information about Genoptix, Inc., please contact Dr. William Butler at wbutler@genoptix.com. Dr. Butler received his Ph.D. degree in Physics from UCSD in 1983 and is Director of Advanced Research & Development for Genoptix, Inc.